Lithium Toxicity and Na+(Li+)/H+ Antiporter in Escherichia coli.
نویسندگان
چکیده
منابع مشابه
Arginine-agmatine antiporter in extreme acid resistance in Escherichia coli.
The process of arginine-dependent extreme acid resistance (XAR) is one of several decarboxylase-antiporter systems that protects Escherichia coli and possibly other enteric bacteria from exposure to the strong acid environment of the stomach. Arginine-dependent acid resistance depends on an intracellular proton-utilizing arginine alpha-decarboxylase and a membrane transport protein necessary fo...
متن کاملAmiloride-sensitive Na+-H+ antiporter in Escherichia coli.
In everted vesicles of Escherichia coli, delta pH caused by H+ efflux through the Na+/H+ antiporter was measured by using a fluorescent dye. Amiloride inhibited the activity of the Na+/H+ antiporter. Kinetic studies showed that amiloride competed with Na+. The inhibition constant of 40 microM was obtained.
متن کاملANTIPORTER NhaA FROM ESCHERICHIA COLI. AN ELECTROPHYSIOLOGICAL STUDY*
gradient for activation, both the wt and the pH-shifted G338S variant exhibit highly symmetrical transport activity with bell shaped pH dependencies, but the optimal pH was shifted 1.8 pH units to the acidic range in the variant. In both strains the pH dependence was associated with a systematic increase of the Km for Na + at acidic pH. Under symmetrical Na + concentration with a pH gradient fo...
متن کاملIron mediates paraquat toxicity in Escherichia coli.
The role of iron ions in paraquat toxicity was studied in bacterial system. We show that addition of ferrous iron led to an enhancement of the bacterial killing, whereas addition of chelating agents, such as nitrilotriacetate and desferrioxamine, markedly reduced, up to a total abolishment, the toxic effects. The calculated rates of bacterial killing are proportional to both paraquat and iron c...
متن کاملMechanism of adenine toxicity in Escherichia coli.
The mechanism of adenine toxicity in an hpt gpt strain of Escherichia coli that is extremely sensitive to adenine inhibition was investigated. Adenine-resistant derivatives had secondary mutations in adeninephosphoribosyltransferase or the purR repressor. Growth studies with various purine salvage pathway mutants and the ability of guanosine to prevent adenine toxicity indicated that adenine ex...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biological and Pharmaceutical Bulletin
سال: 1994
ISSN: 0918-6158,1347-5215
DOI: 10.1248/bpb.17.395